Magento

I would like to know if Magento can have pricing that changes based on the selections of multple drop downs.
For example:
http://www.printrunner.com/business-cards.aspx
(on the rigth there is an instant pricing module).

I would like to do a printing site but the price changes depending on several options.

Thanks.

its possible yes

You can use configurable products or custom options.  Please check the magento demo, product “My Computer”