Sure can! I’ve attached a couple of screenshots of the kind of thing I’m looking for.
So as an example, a Ski center is open on Monday and Tuesday but not Wednesday, and only has time slots between 10-11AM, so I only want to be able to allow customers to book those times.
This is all I’ve come across so far but I don’t need all of the functionality > http://www.magentocommerce.com/magento-connect/booking-and-reservations.html
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